Carcinomas classified as Neo-Bioscore = 0–3 (48.4%; 150/310) prevailed in premenopausal status (55.3; 83/150), histological grade I/II (76.7%; 115/150), ER Allred 7–8 (56.0%; 84/150), Ki-67 < 50% (64.0%; 114/150), negative HER2 (66.7%; 100/150), non-TN subtype (80.7%; 121/150), size T1/T2 (58.7%; 88/150), node-positive axilla (59.3%; 89/150) and stage I/II (60.7%; 91/150). This evidence concerns the gene ESR1 and carcinoma.