ESR1 and carcinoma: Carcinomas classified as Neo-Bioscore = 4–5 (42.6%; 132/310) prevailed in postmenopausal status (58.3%; 77/132), histological grade III (65.9%; 87/132), negative ER (50.8%; 67/132), Ki-67 ≥ 20% (75.8%; 100/132), negative HER2 (84.1%; 111/132), non-luminal A subtype (80.3%; 106/132), size T3/T4 (82.6%; 109/132), positive axilla (84.8%; 112/132) and stage III (80.3%; 106/132).