The pCR carcinoma was about 13.8% (43/310) of the total with histological grade III (62.8%), negative ER (74.4%), Ki-67 ≥ 20% (88.4%), HER2 and TN (93%) subtypes, T3/T4 size (69.8%), N1 axilla (48.8%) and stage III (58.1%). This evidence concerns the gene ESR1 and carcinoma.