TP53 and neoplasm: USP10 is known to act as a tumor suppressor by stabilizing p53 and regulating MDM2-induced p53 nuclear export and degradation [131,132], and USP14 is required for the degradation of the chemokine receptor CXCR4 [133] and is able to inhibit endoplasmic reticulum-associated degradation (ERAD) via interaction with inositol-requiring enzyme-1α (IRE-1α) [134].