USP28 and malignant colon neoplasm: While reports have indicated that a lack of USP28 could reduce colon cancer in mice [114] and that USP28 could also be a prognostic marker in bladder [115] and gastric cancers [116], a lack of USP28 promoted liver cancer and correlated with a worse survival of patients with invasive ductal breast carcinoma: Mouse xenograft experiments with USP28-lacking breast cancer cells supported these findings [117].