HOTAIR and familial pancreatic carcinoma: Curcumin also caused the modulation of tumor suppressor HOTAIR in pancreatic cancer [13], prostate cancer [88], hepatocellular carcinoma (HCC) [84,86], nasopharyngeal carcinoma (NPC) [81], breast cancer [87], lung cancer [80], and renal cancer [62,84,85,86,87,104,127].