A recent in vitro study found that the expressions of resistin (RETN), TNF-α, and C-C motif chemokine ligand 2 (CCL2) of mouse and human pre-adipocytes/adipocytes, were increased by IHR via down-regulation of miR-452, which may play a protective role in the development of insulin resistance [73]. Here, CCL2 is linked to Insulin resistance.