IL6 and neurodegenerative disease: As in other neurodegenerative diseases, neuroinflammation was detected in HD patients as well as in HD animal models like the R6/2 mice [59,60,61,62,63,64,65], in which pro-inflammatory cytokines such as interleukin 6 (IL-6) and tumor necrosis factor alpha (TNFα) were significantly elevated.