Increasing MCP-1 increased VT and MCS, which contradicts the data on the disease activity in SLE, where the serum, cerebrospinal and urinary MCP-1 levels were increased with disease exacerbation; and MCP-1 was also shown to be associated with fatigue and depression in SLE; while simultaneously beingnegatively associated with all SF-36 items, (all, p < 0.01) [4]. Here, CCL2 is linked to major depressive disorder.