As regards mutations, IKZF3 and FLT3 mutations were observed in near-haploid (25–30 chromosomes) patients, as previously reported [73]; low hypodiploidy (31–39 chromosomes) cases displayed TP53 mutations, that were also present in 3/3 high hypodiploidy cases, suggesting that the mutational patterns are similar in low hypodiploid and high hypodiploid ALL. The gene discussed is TP53; the disease is acute lymphoblastic leukemia.