In the study by Yasuda et al. RNA-seq was applied to analyse a cohort of 73 adolescent and young adults ALL cases (AYA-ALL; 15–39 years old) and frequent insertion of D4Z4 repeats containing the DUX4 gene in the IGH locus was found, causing overexpression of DUX4 protein with an aberrant C terminus [47]. This evidence concerns the gene DUX4 and acute lymphoblastic leukemia.