A subclass of Ph-like ALL is characterized by chromosomal rearrangements involving the erythropoietin receptor gene, EPOR. In 2016, in a study by Iacobucci et al., the incidence of EPOR rearrangements was analysed by WGS and RNA-seq in 3115 childhood, adolescent and young adult B-ALL patients, including 212 cases with a Ph-like ALL gene expression profile. The gene discussed is EPOR; the disease is precursor B-cell acute lymphoblastic leukemia.