To explore the pathogenic mechanisms of relapse and to detect the occurrence of NOTCH1/FBXW7 alterations in relapsed T-ALL, a WES study was conducted in 30 paediatric patients, among which 11 diagnosis-relapse paired cases [104] NOTCH1/FBXW7 mutations were identified in 73.3% of cases at the onset and 72.7% of the relapses. Here, NOTCH1 is linked to acute lymphoblastic leukemia.