WES and targeted sequencing were performed in 168 cases including children, AYA and adults to investigate the pathogenic landscape of the so-called B-NEG ALL, i.e., ALL cases negative for the known fusion transcripts, such as BCR-ABL1, ETV6-RUNX1, E2A-PBX1, and MLL rearrangements [69]. The gene discussed is KMT2A; the disease is acute lymphoblastic leukemia.