PAX5 and acute lymphoblastic leukemia: An inherited predisposition to ALL is rare; however, some inherited variants have been demonstrated to increase the risk of susceptibility to ALL [74,75,76,77,78,79,80,81,82,83,84], and several familial ALL cases were characterized by inherited deleterious mutations [73,85,86] in key genes as such as TP53, RAS signalling components [73], and PAX5 [85,87].