INS and type 2 diabetes mellitus: Indeed, after an exhaustive search of methylation databases and in a subpopulation of the Methyl Epigenome Network Association (MENA) study (n = 417, females = 59%, T2D = 59, non-T2D = 358), we have not been able to validate our CpGs in insulin-resistant individuals or with T2D (data not shown).