Here, we report that long-term treatment with SkQ1 (250 nmol/[kg body weight] daily from the age of 1.5 to 22 months) suppressed the development of the AMD-like pathology in OXYS rats by reducing the level of Aβ and suppressing the activity of mTOR in the retina. The gene discussed is MTOR; the disease is age-related macular degeneration.