Costunolide induced mitochondria-mediated apoptosis as evidenced by the inhibition of Bcl-2, induction of Bax, and release of cytochrome c in human prostate (PC3 and DU-145) [60], leukemia (K562) [48], oral cancer (Eca-109) [59], gastric cancer (SGC-7901) [54], lung squamous carcinoma (SK-MES1) [53], and bladder cancer (T24) [61] cells. Here, BCL2 is linked to lip and oral cavity carcinoma.