Similarly, HDL isolated from patients with breast cancer complicated with T2DM promoted an increase in breast cancer cell adhesion to HUVECs and stimulated higher intercellular adhesion molecule 1 (ICAM-1) and vascular cell adhesion molecule 1 (VCAM-1) expression on the cell surfaces of breast cancer cells and HUVECs, along with the activation of PKC, compared with HDL isolated from breast cancer patients. Here, ICAM1 is linked to type 2 diabetes mellitus.