VEGFA and neoplasm: Signal transducer and activator of transcription (STAT)-3 is an important transcription factor that can target c-Myc, vascular endothelial growth factor (VEGF), cyclin D1, matrix metalloproteinase (MMP) 2, and MMP9 to promote the development of cancer involving tumor proliferation, invasion, metastasis, and angiogenesis [57].