APOE and metabolic syndrome: The role of dyslipidemia in breast cancer growth and metastasis was also explored in hypercholesterolemic apolipoprotein E knockout mice (apoE–/–) fed an HFHC diet and injected with non-metastatic Met-1 and metastatic Mvt-1 mammary cancer cells derived from PyMT mice and c-Myc/vegf tumor explants, respectively [41].