BCL2 and neuroblastoma: RA, also, can induce apoptosis, modulating the expression of both proapoptotic and antiapoptotic Bcl-2 proteins; indeed, in neuroblastoma cells [94], metastatic melanoma [95] and myeloblastic leukemia cells [96], it has been confirmed that apoptosis induced by RA is accompanied by downregulation of Bcl2 with subsequent activation of caspases 9 and 3.