Consistent with the findings in an obese mice model [48], miR-221 was upregulated in obese individuals and targeted adiponectin receptor 1 (ADIPOR1), which encodes for a receptor of adiponectin and ETS proto-oncogene 1 (ETS1), a member of ETS family of transcription factors, suggesting a relationship with the development of IR and T2D in obesity [68]. Here, ADIPOR1 is linked to obesity due to melanocortin 4 receptor deficiency.