In this study, we have used logistic regression-based meta-analysis, a quantitative review method to detect the diagnostic value of different biomarkers in medical researches [29], and a huge number of gene expression (GE) data for different populations from the Gene Expression Omnibus (GEO) database, as a well-known biomedicine database, to investigate the diagnostic value of CHGA expression as a biomarker, compared to the healthy populations and the normal mucosa from the colon cancer patients. The gene discussed is CHGA; the disease is malignant colon neoplasm.