A logistic regression-based meta-analysis was used to analyze the significant roles and functions of CHGA expression as a novel and promising significant biomarker for early diagnosis of colon cancer patients, and to compare CHGA in early diagnosis with the well-known oncogene, KRAS, tumor suppressor, TP53, and cellular proliferative factor, MKI67, in colon cancer. This evidence concerns the gene TP53 and malignant colon neoplasm.