COR promotes the apoptosis of tumor cells through various pathways in vitro, for example, COR represses the transcription of MET in the multiple myeloma cell line MM.1S [58], activates the ROS-mediated mitochondria pathway (ROS/caspase-8/caspase-3/PARP) and induces autophagy in the Leydig tumor cell line MA-10 in a dose-dependent manner [59] and stimulates p53 signaling (A2AR/p53/caspase-7/PARP) in the glioma cell line C6 (malignant tumor cell) [60]. Here, CASP8 is linked to cancer.