In IL-1β-induced human osteoarthritis chondrocytes in vitro, COR exhibits anti-inflammatory effect via the inhibition of the p65 NF-κB pathway (IκB-α/p65 NF-κB/COX-2/PGE2/iNOS/NO/MMP-13 /IL-6) [66]. Here, NFKB1 is linked to osteoarthritis.