Additionally, previous work demonstrated that COR arrests the cancer cell cycle at the G1 phase in vitro via the PI3K/Akt pathway (Akt/GSK-3b/β-catenin/cyclinD1) in the leukemia cell line U937 [41] and the CDKIs (p21/p27)/Cyclin(D1 and E) pathway in the leukemia cell line BCRC60176 [42]. This evidence concerns the gene CCND1 and cancer.