Furthermore, COR stimulates apoptosis by inhibiting the PI3K/Akt pathway (PI3K/Akt/hTERT/telomerase) inleukemia cell line (U937 and THP-1) in vitro [33] and induces autophagy (type II cell death) in the breast cancer cell line MCF-7 in vitro [32]. Here, AKT1 is linked to breast cancer.