In addition, COR inhibits migration and invasion via MMP-mediated pathways in vitro, for example, COR suppressed the AKT pathway (AKT/MMP-9/MMP-2) in the prostate cancer cell line LNCaP [49], repression of MMP-9/MMP-2 in in vitro lung cancer cell line CL1-0 [50] and inhibited the AP-1 pathway (TPA/AP-1/MMP-9) in the breast cancer cell line MCF-7 [51]. This evidence concerns the gene MMP9 and Familial prostate cancer.