The present study indicated that CRCR showed significantly therapeutic effects on migraine via increasing cerebral blood flow, decreasing the expression of CGRP and c-Fos mRNA, and regulating the releasing of ET-1, GABA, NOS, 5-HT, 5-HIAA, CGRP and β-EP in the serum and brainstem. This evidence concerns the gene FOS and migraine disorder.