HMGB1 and pleural mesothelioma: Serum mesothelin has been identified as a biomarker for the detection of pleural mesothelioma but with limited results [24] while other researchers have investigated the role of serum levels of High Mobility Group Box 1 protein (HMGB1) [25], ostheopontin [26], proteomics-based approaches [27], fibulin-3 and microRNAs [26,28].