siRNA transfection groups (2.54% ± 0.47%, 3.56% ± 0.43%, and 2.16% ± 0.26 in H1975, H1650, and LTEP-a2 cells, respectively), indicating that TIRAP participated in the apoptotic regulatory processes in multiple NSCLC cells. Here, TIRAP is linked to non-small cell lung carcinoma.