However, data from our aforementioned transcriptome analysis show that, at TW4, patients who developed depression had a higher expression of a distinct set of genes, including cyclin dependent kinase 5 (CDK5) and CDK8, as well as insulin-like growth factor-binding protein 5 (IGFBP5) and IGFBP7 (Hepgul et al., 2016), which are known to regulate both cell proliferation and differentiation (Alexander et al., 2004, Tanno et al., 2005). This evidence concerns the gene IGFBP5 and major depressive disorder.