The immune system undergoes significant maturation during childhood and it is evident from several epidemiological studies that the first 10 years of life are special in terms of the IgE profile and clinical manifestations; hence the term “allergic march” is often used to describe this phenomenon.7, 8 The mechanisms of the allergic march are still poorly understood and longitudinal investigations of clinical allergy in cohorts where both IgE sensitization and doctor's diagnosed allergy are considered are most important for understanding. The gene discussed is IGHE; the disease is allergic disease.