HOTAIR and gastric cancer: Recently, plenty of studies have reported that the aberrantly expressed lncRNAs, including that of HOTAIR, H19, UCA1, MEG3, and MALAT1 significantly regulate GC cell cycle, cell proliferation, apoptosis, migration, invasion, metastasis, and tumorigenicity.4, 5 Meanwhile, due to the functional diversity of lncRNAs, identifying abnormally expressed lncRNAs in GC and deeply investigate the functions and mechanisms remains challenging.