PI3K‐AKT‐mTOR signaling pathway has function as essential role in the carcinogenesis progression regulation of common cancers.20, 21, 22 In this study, the overexpression and siRNA of LOC101928316 can affect the p‐AKT3 and p‐mTOR expression levels, and these key proteins can regulate the carcinogenesis biological processes. The gene discussed is AKT3; the disease is cancer.