Kimura et al6 demonstrated that GAD1 promotes the cancer cell invasion and metastasis of oral cancer by inducing the nuclear translocation of β‐catenin and secretion of MMP7,15, 16, 17, 18, 19, 20 although the regulatory mechanisms of GAD1 in β‐catenin translocation remain unclear. This evidence concerns the gene GAD1 and lip and oral cavity carcinoma.