In this regard, our results suggested the c.1162G > A (p.Gly388Arg) pathogenic variant commonly detected in FGFR4 gene that is known to have a role in cancer progression, and retinal development in patients 1/II‐7, 2/IV‐2, 2/IV‐7, 3/III‐1, and 3/III‐2, might be a candidate mechanism triggering the development of Rb. This evidence concerns the gene FGFR4 and retinoblastoma.