Four genes, C2, CFB, MBL2, and SERPINA1 (p: 0.00055) were found effective in complement and coagulation cascade on the immune system, three genes, C2, CFB, MBL2 (p: 0.008) were found effective in staphylococcus aureus infection and three genes, ATP6V0A4; CLEC7A, MBL2 (p: 0.05) were found effective in the occurrence of cellular phagocytosis and there was an association between mutations and Rb in the study. The gene discussed is C2; the disease is staphylococcus aureus infection.