Reverse transcription quantitative polymerase chain reaction and western blot analysis were conducted in order to evaluate the melanoma‐induced effects through quantification of TYR, Wnt signalling pathway related factors (β‐catenin, LRP6 and LGR5), apoptosis‐related factors (Bcl‐2 and Bax) and proliferation‐related factor (CyclinD1) in the melanoma tissues and the paracancerous tissues. This evidence concerns the gene LGR5 and melanoma.