In summary, by examining the genomic landscape of the hypoxic response in melanoma, our results have revealed a number of unanticipated features of the hypoxic response including transient up‐regulation of MITF by hypoxia, the self‐repression of MITF to provide a negative feedback loop, the limited repertoire of core hypoxia response gene in different melanoma lines, the regulation of MITF by glucose, and the ability of MITF to suppress the hypoxic response by controlling succinate levels via regulation of SDHB. The gene discussed is MITF; the disease is melanoma.