Much of melanoma biology is driven by the activity of the microphthalmia‐associated transcription factor MITF (Goding & Arnheiter, 2019) that promotes differentiation (Carreira et al., 2005) and proliferation (Du et al., 2004), and whose expression is anti‐correlated with invasion (Carreira et al., 2006) and therapy resistance (Dugo et al., 2015; Konieczkowski et al., 2014; Landsberg et al., 2012; Muller et al., 2014; Riesenberg et al., 2015; Tirosh et al., 2016). This evidence concerns the gene MITF and melanoma.