Long non‐coding RNA deleted in lymphocytic leukaemia 1 (DLEU1), located on chromosome 13q14.3,11 has been reported to be up‐regulated and function as oncogene in several types of cancer, including oral squamous cell carcinoma,12 colorectal cancer,13 gastric cancer,14 ovarian cancer15 and endometrial carcinoma.16 However, the role and potential molecular mechanism of DLEU1 in HCC remain unclear. This evidence concerns the gene DLEU1 and oral cavity squamous cell carcinoma.