For example, Liu et al reported that DLEU1 promoted colorectal cancer growth by regulating SMARCA1/KPNA3 axis.13 Shao et al demonstrated that DLEU1 drove the development of endometrial cancer by interacting with miR‐490 to regulate SP1 expression and PI3K/AKT/GSK‐3β pathway.16 Wang et al reported that DLEU1 promoted ovarian cancer tumourigenesis and development by sponging miR‐490‐3p and altering CDK1 expression.15 However, the effects of DLEU1 on HCC, and its underlying molecular mechanisms remain unclear. The gene discussed is SP1; the disease is hepatocellular carcinoma.