TXNIP and cancer: In addition, miR‐224 could be a suitable maker that predicted relapse of colorectal cancer.10 In parallel, miR‐224 was elevated in hepatocellular carcinoma and its overexpression contributed to G1/S checkpoint release and led to accelerating cell growth.21 MiR‐224 was increased in advanced melanoma expression and drove EMT through TXNIP down‐regulation.22 In addition, up‐regulation of miR‐224 was associated with aggressive progression and poor prognosis in human cervical cancer.23 However, miR‐224 functioned as a tumour‐suppressor in some types of cancer.