For instance, miR‐224 decreased cell proliferation and migration via down‐regulating Fizzled 5 expression in breast cancer.24 Restoration of miR‐224 inhibited cell proliferation, migration and invasion in osteosarcoma.25 MiR‐224 inhibited cancer cell migration and invasion via targeting oncogenic TPD52 in prostate cancer.26 However, the role of miR‐224 in OSCC has seldom been investigated. Here, TPD52 is linked to Familial prostate cancer.