ADAM17, as well as many other ADAM family members, is known to process single‐spanning membrane proteins such as cytokines, growth factors and regulators of cancer processes.12 Abnormal expression of ADAM17 is usually found in a series of cancer, such as ovarian cancer, colon cancer, breast cancer and OSCC.13, 14, 15 ADAM17 can be a novel therapeutic target for these cancers. The gene discussed is ADAM17; the disease is colonic neoplasm.