NLRC5 belongs to NLR family and plays a physiologically important role in the maintenance of immune homoeostasis.43 Recently, the oncogenic role of NLRC5 in human tumours immensely attracts people's attention.44, 45 In our research, the expression levels of NLRC5 were found that significantly elevated in glioma tissues and cell lines. Here, NLRC5 is linked to central nervous system cancer.