NLRC5 belongs to NLR family and plays a physiologically important role in the maintenance of immune homoeostasis.43 Recently, the oncogenic role of NLRC5 in human tumours immensely attracts people's attention.44, 45 In our research, the expression levels of NLRC5 were found that significantly elevated in glioma tissues and cell lines. This evidence concerns the gene NLRC5 and neoplasm.