Univariate logistic regression revealed that JKAP level was negatively correlated with 28‐day mortality (OR = 0.232, P = 0.002), while APACHE II score (OR = 2.533, P = 0.036), SOFA score (OR = 7.407, P < 0.001), Scr (OR = 2.657, P = 0.026), WBC (OR = 2.353, P = 0.050), CRP (OR = 3.286, P = 0.008), PCT (OR = 2.857, P = 0.018), TNF‐α (OR = 3.810, P = 0.004), IL‐1β (OR = 6.810, P < 0.001), and IL‐17 (OR = 2.500, P = 0.036) were positively associated with 28‐day mortality in sepsis patients (Table 3). The gene discussed is CRP; the disease is Sepsis.