However, APACHE II score (HR = 2.208, P = 0.032), SOFA score (HR = 5.095, P < 0.001), Scr (HR = 2.184, P = 0.031), CRP (HR = 2.369, P = 0.020), PCT (HR = 2.447, P = 0.015), TNF‐α (HR = 2.316, P = 0.023), and IL‐1β (HR = 4.920, P < 0.001) were negatively associated with accumulating survival in sepsis patients. This evidence concerns the gene TNF and Sepsis.