The AD patients included in our cohort did not display increased Q-albumin compared to the NCs and we cannot therefore exclude the possibility that analysis on an AD patient group with increased Q-albumin would yield elevated levels of uIAPP in likeness to the study by Fawver et al. It should further be pointed out that the strong correlation between Q-albumin and total IAPP found in all groups also could indicate an impact of modified or aggregated IAPP on BBB intactness. Here, IAPP is linked to Alzheimer disease.