IAPP and Alzheimer disease: To further investigate if alterations in IAPP levels in AD patients can be found when both modified and unmodified IAPP are analyzed, we examined CSF levels using Western Blot analysis with three different antibodies (4149, 4157 and A133) directed against epitopes unaffected by modifications in the N- and C-terminal regions (i.e. both modified and unmodified IAPP).