IFIT3 and infection: Consistent with the key role of fat-6 and fat-7 in the regulation of innate immune responses, the fold induction of the innate immune effectors irg-4, irg-5, irg-6, irg-1, and irg-2 during pseudomonal infection was significantly attenuated in the fat-6(tm331);fat-7(wa36) double mutant compared to wild-type (Fig 4B).