IGHG3 and Wilson disease: Moreover, levels of IgG3, a specific subclass of IgG that is mainly produced by MZB cells via a T cell-independent pathway under pre-immune conditions or after immunization [23, 24], were significantly lower in lubiprostone- or Mg(OH)2-gavaged mice than in mice in the WD alone group (p<0.05; Fig 7B).