ITGAX and colitis: While we propose intDCs from the cLP to be the most important cell type to promote inflammation-preventing events during DSS-induced colitis, Uematsu and colleagues demonstrated CD11c+ cells from Peyer’s Patches (PPs) in the small intestine to be responsible for flagellin-induced IL-10 secretion, which might, in turn, contribute to homeostasis, while LP CD11c+ cells instead promote secretion of proinflammatory cytokines [85].