REST and infection: This design restricted the expression of REST to cells expressing Cre recombinase.33 The experiment had the following rationale: after the tamoxifen injection, the DRG neurons in RestloxP/loxP/AvCreER-T2 mice will start expressing Cre; this will cause REST deletion but on the other hands, this would also make these neurons specifically susceptible to infection by the AAV2/9-DIO-REST virions.