Upregulation of REST after peripheral nerve injury has been shown to correlate with the downregulation of some of its target genes in DRG, including Kcnd3,39Kcnq2,30Scn10a,38 and Oprm138,44; these genes are coding for Kv4.3, Kv7.2, Nav1.8 ion channels and μ-opioid receptors, respectively. This evidence concerns the gene SCN10A and peripheral nerve injury.