Although AFP combined with CA19-9 and CEA, has a specificity of 100% and a positive predictive value of 100% its low sensitivity of 2.5 % makes it use as a screening tool inferior to AFP alone in HCC and differentiating HCC from non-HCC patients, and therefore not a suitable substitute in screening of potential HCC patients, however it can aid in the definitive diagnosis of HCC and exclude HCC as the primary. Here, CEACAM5 is linked to hepatocellular carcinoma.