PLAT and Stroke: The TRUST-tPA trial (Therapeutic Trial Evaluating Efficacy of Telemedicine (TELESTROKE) of Patients With Acute Stroke) established a tele-stroke network of 10 community hospital emergency rooms that were connected to a stroke center; eligible patients were assigned to a usual care arm in which they were transferred to the stroke center for intravenous recombinant tissue plasminogen activator (IV rt-PA) administration, or to the tele-thrombolysis arm in which patients were evaluated by tele-neurology, administered IV rt-PA, and then transferred to a stroke center.