PTEN and cancer: In addition, the higher rate of mutation frequencies in previous studies indicated that genes ERBB2, PTEN, PTGS2 and CDH1 are involved in the regulation cancers in women (Kuusisto et al., 2011; Liao & Dickson, 2000; Revillion, Bonneterre & Peyrat, 1998; Smith, Kappler & Ethier, 2017).