PTGS2 and cancer: MMP14, MDM2, ERBB2, SKP2 and PTGS2, which were previously identified as OGs in human cancer (Gstaiger et al., 2001; Ling et al., 2017; Madson et al., 2006; Majumder et al., 2015; Zhang & Wang, 2000), also have higher rate of amplification in mutation data.