We found significantlyincreased levels of the Th17-related cytokine IL-6 in the CSF as well as IL-8(Th17-related), APRIL (B cell-related), GRO-α and MIP-1β (broad spectrum-related) inthe serum of patients with AQP4-Ab, MOG-Ab and NMDAR-Ab as compared to MS, which wecould confirm in a validation set. This evidence concerns the gene CCL4 and myeloid sarcoma.