They found higher degree of methylation of MGMT, RARβ, RASSF1A, and CDH13 in tumour specimens and of SOCS-1 in peripheral blood with higher levels of IL-6, while others found less degree of methylation of USP2, TMEM49, SMAD3, DTNB, and IL-6 promoter with higher levels of IL-6. The gene discussed is SMAD3; the disease is neoplasm.