IL-1β +3954 polymorphism was successfully genotyped in all SCD patients and control groups and revealed the following distribution: CC genotype was found in 20 (40%) cases vs. 18 (36%) in control group; the CT genotype was found in 17 (34%) cases vs. 29 (58%) in control group and the homozygous mutant TT genotype was detected in 13 (26%) cases vs. 3 (6%) in control group. Here, IL1B is linked to Schnyder corneal dystrophy.