In October 2015, pembrolizumab was approved for treatment of previously treated advanced or metastatic PD-L1-positive (at least 1%) NSCLC, based on the results of the randomized phase 1b trial KEYNOTE-001 [57], in which patients received pembrolizumab 2 or 10 mg/kg every 3 weeks or 10 mg/kg every 2 weeks. Here, CD274 is linked to non-small cell lung carcinoma.