SESN2 and obesity due to melanocortin 4 receptor deficiency: Of note, SESN2 is induced upon hypernutrition, and the genetic ablation of SESN2 exacerbates obesity-induced mTORC1-S6K activation, glucose intolerance, insulin resistance, and hepatosteatosis in the liver of obese mice, all of which are rescued by AMPK pharmacological activation [80].