ERBB2 and invasive lobular breast carcinoma: Whereas HER-2, ER and PR are used as predictive factors, c-MET aberrations (mutations or amplification) are indicators of high-grade invasive breast lobular carcinomas with increased metastatic risk and are commonly identified in triple negative basal-like cases [15] that represent below 2% of all invasive lobular carcinomas of the breast [16].