INS and type 2 diabetes mellitus: Several data suggest that infections resulting from periodontal or gut microbes have a direct influence on our endocrine system, on PVAT, and on pituitary-suprarenal action, with a possible derived imbalance of the autonomic sympathetic nervous system and metabolism homeostasis that could induce hypertension, insulin peripheral resistance, T2DM, increase of LDL-cholesterol and triglycerides, decrease of HDL cholesterol associated to an even more oxidative burden by ROS overproduction, and restenosis phenomenon [28, 84].