How melanoma cells evade antibody-mediated phagocytosis remains unclear, although our data show that CD47 blocking antibodies effectively bind to and block CD47 on the surface of melanoma cells and that resistance is not mediated by melanoma secreted factors, by the inability to upregulate ‘eat-me’ signals, or by the expression of a large array of ‘don’t eat me’ signals. Here, CD47 is linked to melanoma.