Among the 10 most upregulated genes in Gorlin 1 DDX3XR351W tumors (compared to Gorlin 1 tumors), genes previously implicated in tumor growth and malignancy include HOXA3, HOXB3, KRT6A, and S100A9 (Chen et al., 2013, Inanc et al., 2014, Lim et al., 2016, Zhang et al., 2018) (Table S3). This evidence concerns the gene S100A9 and neoplasm.