Among the 10 most upregulated genes in WTC10 MYCN tumors compared to NES cells (Table S1), genes previously linked to cancer progression and malignancy include AVP, BARHL1, HELT, and LMX1A (Pöschl et al., 2011, Sun et al., 2007, Sun et al., 2017, Tsai et al., 2013). The gene discussed is HELT; the disease is cancer.