Among the 10 most upregulated genes in GSE1−/− tumors compared to Gorlin 1 tumors, genes associated with cancer include CTSG, ELANE, HIST1H3C, NNAT, PEG3, PRTN3, and RNLS (Alatrash et al., 2017, Decock et al., 2012, Guo et al., 2016, Houghton et al., 2010, Hu et al., 2018, Özata et al., 2017, Siu et al., 2008) (Table S3). This evidence concerns the gene H3C3 and cancer.