Among the 10 most upregulated genes in Gorlin 1 DDX3XR534S tumors (compared to Gorlin 1 tumors), genes previously linked with cancer include DDX43, KRT7, HOXB3, and NNAT (Ambrosini et al., 2014, Huang et al., 2016, Lindblad et al., 2015, Siu et al., 2008) (Table S3). This evidence concerns the gene HOXB3 and cancer.