SHH and medulloblastoma: Patients with Turcot’s syndrome, who have a germline mutation in the adenomatous polyposis of the colon (APC) gene (Hamilton et al., 1995), are predisposed to WNT-subtype medulloblastoma, which has a more indolent clinical course than SHH-subtype medulloblastoma (Northcott et al., 2019).