This bias toward neuronal lineages may explain why transformed NES cells (both Gorlin and MYCN driven) resemble medulloblastoma more than other brain tumor types thought to be derived from glial lineages such as glioblastoma, ependymoma, and pilocytic astrocytoma (Figures 2B, S2B, 4D, and S4A). This evidence concerns the gene MYCN and ependymoma.