Among the 10 most upregulated genes in Gorlin 1 NES cells compared to Gorlin 2 NES cells, the genes linked to tumor growth and malignancy that might contribute to the difference in latency included CYP24A1, FZD10, and HIST1H3C (Decock et al., 2012, Shiratsuchi et al., 2017, Terasaki et al., 2002) (Table S2). This evidence concerns the gene CYP24A1 and neoplasm.