BCR and lymphoma: The authors of the previous study also found that shRNA targeting of Btla in hematopoietic cells (HSCs) led to GC lymphomas and attributed this to a mechanism whereby cis engagement of BTLA by HVEM leads to BTLA-mediated downregulation of tumor-promoting BCR signals (Boice et al., 2016, Huet et al., 2018, Verdière et al., 2018).