Lastly, while we were not able to identify a target gene at the chromosome 16q12.2 locus, we found a genetically regulated putative enhancer in the first intron of FTO (MIM: 610966) (H3K27ac-70404; chr16: 53,812,377–53,812,817) with evidence of underlying GWAS associations in this locus with type 2 diabetes, HDL, and triglyceride levels (Figure 6D). This evidence concerns the gene FTO and type 2 diabetes mellitus.