IRF8 and hereditary disease: We also note that mutations in four of the complex phenotype-causing genes, LIPA (MIM: 613497), LIPC (MIM: 151670), GPIHBP1 (MIM: 612757), and IRF8 (MIM: 601565), have been implicated in related Mendelian diseases,90, 91, 92, 93 and 50% of the trait-relevant genes that have murine models were reported to display similar phenotype in the model organism as well (Mouse Genome Database; Table S11).