To assess whether HCMV can induce COX-2 and 5-LO expression in breast cancer cell lines, we infected MCF-7 and MDA-MB-231 with HCMV strain VR1814 at MOI of 5 and analyzed transcript levels of COX-2 and 5-LO by qPCR at 1, 3, and 6 dpi. The gene discussed is PTGS2; the disease is breast cancer.