PTGS2 and neoplasm: In addition, combined antiviral therapy targeting HCMV (Valganciclovir) and COX-2 (Celecoxib) prevents HCMV replication and PGE2 production, further reduced meduloblastoma and neuroblastoma cell proliferation in vitro (Baryawno et al. 2011; Wolmer-Solberg et al. 2013) and tumor size in meduloblastoma xenografts (Baryawno et al. 2011).