SOD1 and amyotrophic lateral sclerosis: In the widely used SOD1-G93A humanised transgenic ALS model, female mice exhibit later onset of disease and prolonged survival versus males in some but not all inbred strains, demonstrating genetic background-dependent effects, consistent with an increased incidence of ALS in males (Heiman-Patterson et al. 2005; Pfohl et al. 2015).