Some studies have looked at the effects of different inbred genetic backgrounds on mouse models of disease, for example, as in SOD1-G93A ALS mice, demonstrating strain-specific effects on disease onset, progression, and lifespan (Acevedo-Arozena et al. 2011; Heiman-Patterson et al. 2011). Here, SOD1 is linked to amyotrophic lateral sclerosis.