APOE and Alzheimer disease: For example, astroglia make a significant contribution to AD pathogenesis, through dysregulation of inflammation that can influence amyloid beta levels, or through production of APOE4 variants (astrocytes primarily produce APOE4 and regulate neuronal APOE) (Gonzalez-Reyes et al. 2017; Harris et al. 2004; Oksanen et al. 2017).